10.6084/m9.figshare.8294402.v1 Ashleigh Downing Ashleigh Downing Hoda Eid Hoda Eid Andrew Tang Andrew Tang Fida Ahmed Fida Ahmed Cory Harris Cory Harris Pierre Haddad Pierre Haddad Timothy Johns Timothy Johns John Arnason John Arnason Steffany Bennett Steffany Bennett Alain Cuerrier Alain Cuerrier Additional file 6: of Growth environment and organ specific variation in in-vitro cytoprotective activities of Picea mariana in PC12 cells exposed to glucose toxicity: a plant used for treatment of diabetes symptoms by the Cree of Eeyou Istchee (Quebec, Canada) Springer Nature 2019 Traditional medicine PC12-AC UPLC-QTOF DPPH Phenolics Stilbenes Glucose toxicity 2019-06-18 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_6_of_Growth_environment_and_organ_specific_variation_in_in-vitro_cytoprotective_activities_of_Picea_mariana_in_PC12_cells_exposed_to_glucose_toxicity_a_plant_used_for_treatment_of_diabetes_symptoms_by_the_Cree_of_Eeyou_Istchee_Quebec_Canad/8294402 Figure S6. Taxifolin protects PC12 cells from high glucose-mediated death. Exposure to glucose toxicity produced a significant loss in cell viability compared to normal glucose conditions as assessed by mitochondrial dehydrogenase activity measured by cleavage of the formazan dye WST [left panel, ** denotes a significant difference (p < 0.01) relative to normal glucose control, Student’s t-test, n = 16]. Three concentrations of taxifolin (0.8, 1.6 and 3.2 μM) were administered to high glucose-treated cells. Cytoprotective activity was assessed as described in methods section. *denote significant differences (p < 0.05) between high glucose and taxifolin sample (ANOVA, post-hoc Dunnett’s t-test, n = 10–15). Data are reported as the mean ± SEM. (PDF 618 kb)