10.6084/m9.figshare.8294402.v1
Ashleigh Downing
Ashleigh
Downing
Hoda Eid
Hoda
Eid
Andrew Tang
Andrew
Tang
Fida Ahmed
Fida
Ahmed
Cory Harris
Cory
Harris
Pierre Haddad
Pierre
Haddad
Timothy Johns
Timothy
Johns
John Arnason
John
Arnason
Steffany Bennett
Steffany
Bennett
Alain Cuerrier
Alain
Cuerrier
Additional file 6: of Growth environment and organ specific variation in in-vitro cytoprotective activities of Picea mariana in PC12 cells exposed to glucose toxicity: a plant used for treatment of diabetes symptoms by the Cree of Eeyou Istchee (Quebec, Canada)
Springer Nature
2019
Traditional medicine
PC12-AC
UPLC-QTOF
DPPH
Phenolics
Stilbenes
Glucose toxicity
2019-06-18 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_6_of_Growth_environment_and_organ_specific_variation_in_in-vitro_cytoprotective_activities_of_Picea_mariana_in_PC12_cells_exposed_to_glucose_toxicity_a_plant_used_for_treatment_of_diabetes_symptoms_by_the_Cree_of_Eeyou_Istchee_Quebec_Canad/8294402
Figure S6. Taxifolin protects PC12 cells from high glucose-mediated death. Exposure to glucose toxicity produced a significant loss in cell viability compared to normal glucose conditions as assessed by mitochondrial dehydrogenase activity measured by cleavage of the formazan dye WST [left panel, ** denotes a significant difference (p < 0.01) relative to normal glucose control, Student’s t-test, n = 16]. Three concentrations of taxifolin (0.8, 1.6 and 3.2 μM) were administered to high glucose-treated cells. Cytoprotective activity was assessed as described in methods section. *denote significant differences (p < 0.05) between high glucose and taxifolin sample (ANOVA, post-hoc Dunnett’s t-test, n = 10–15). Data are reported as the mean ± SEM. (PDF 618 kb)