10.6084/m9.figshare.8288342.v1 Noah Berlow Noah Berlow Rishi Rikhi Rishi Rikhi Mathew Geltzeiler Mathew Geltzeiler Jinu Abraham Jinu Abraham Matthew Svalina Matthew Svalina Lara Davis Lara Davis Erin Wise Erin Wise Maria Mancini Maria Mancini Jonathan Noujaim Jonathan Noujaim Atiya Mansoor Atiya Mansoor Michael Quist Michael Quist Kevin Matlock Kevin Matlock Martin Goros Martin Goros Brian Hernandez Brian Hernandez Yee Doung Yee Doung Khin Thway Khin Thway Tomohide Tsukahara Tomohide Tsukahara Jun Nishio Jun Nishio Elaine Huang Elaine Huang Susan Airhart Susan Airhart Carol Bult Carol Bult Regina Gandour-Edwards Regina Gandour-Edwards Robert Maki Robert Maki Robin Jones Robin Jones Joel Michalek Joel Michalek Milan Milovancev Milan Milovancev Souparno Ghosh Souparno Ghosh Ranadip Pal Ranadip Pal Charles Keller Charles Keller Additional file 14: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma Springer Nature 2019 Personalized therapy Combination therapy Artificial intelligence and machine learning Pediatric cancer Sarcoma Drug screening High-throughput sequencing Computational modeling 2019-06-17 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_14_of_Probabilistic_modeling_of_personalized_drug_combinations_from_integrated_chemical_screen_and_molecular_data_in_sarcoma/8288342 Figure S14. Heat map of IC50 and EC50 values for Pediatric Preclinical Testing Initiative Version 3 drug screen compounds inhibiting mutated and expressed targets in PCB490. Red in the IC50 and EC50 tables indicates low IC50 and EC50 values, respectively. No single target or combination of targets showed uniform efficacy across all PCB490 cultures, suggesting variations alone or in conjunction with transcriptome sequencing would not have identified actionable therapeutic targets. Heat values in the IC50 section of the table represent drug sensitivities as IC50 values, between 1 nM (red) and 6 μM or above (white). Heat values in the EC50 section of the table represent quantified drug-target interaction between chemical agents and gene targets, quantified as 50% inhibitory concentrations between 1 nM (red) and 6 μM or above (white), with grey representing no interaction. (TIF 13895 kb)