10.6084/m9.figshare.8288342.v1
Noah Berlow
Noah
Berlow
Rishi Rikhi
Rishi
Rikhi
Mathew Geltzeiler
Mathew
Geltzeiler
Jinu Abraham
Jinu
Abraham
Matthew Svalina
Matthew
Svalina
Lara Davis
Lara
Davis
Erin Wise
Erin
Wise
Maria Mancini
Maria
Mancini
Jonathan Noujaim
Jonathan
Noujaim
Atiya Mansoor
Atiya
Mansoor
Michael Quist
Michael
Quist
Kevin Matlock
Kevin
Matlock
Martin Goros
Martin
Goros
Brian Hernandez
Brian
Hernandez
Yee Doung
Yee
Doung
Khin Thway
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Thway
Tomohide Tsukahara
Tomohide
Tsukahara
Jun Nishio
Jun
Nishio
Elaine Huang
Elaine
Huang
Susan Airhart
Susan
Airhart
Carol Bult
Carol
Bult
Regina Gandour-Edwards
Regina
Gandour-Edwards
Robert Maki
Robert
Maki
Robin Jones
Robin
Jones
Joel Michalek
Joel
Michalek
Milan Milovancev
Milan
Milovancev
Souparno Ghosh
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Ranadip Pal
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Charles Keller
Charles
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Additional file 14: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
Springer Nature
2019
Personalized therapy
Combination therapy
Artificial intelligence and machine learning
Pediatric cancer
Sarcoma
Drug screening
High-throughput sequencing
Computational modeling
2019-06-17 05:00:00
Figure
https://springernature.figshare.com/articles/figure/Additional_file_14_of_Probabilistic_modeling_of_personalized_drug_combinations_from_integrated_chemical_screen_and_molecular_data_in_sarcoma/8288342
Figure S14. Heat map of IC50 and EC50 values for Pediatric Preclinical Testing Initiative Version 3 drug screen compounds inhibiting mutated and expressed targets in PCB490. Red in the IC50 and EC50 tables indicates low IC50 and EC50 values, respectively. No single target or combination of targets showed uniform efficacy across all PCB490 cultures, suggesting variations alone or in conjunction with transcriptome sequencing would not have identified actionable therapeutic targets. Heat values in the IC50 section of the table represent drug sensitivities as IC50 values, between 1 nM (red) and 6 μM or above (white). Heat values in the EC50 section of the table represent quantified drug-target interaction between chemical agents and gene targets, quantified as 50% inhibitory concentrations between 1 nM (red) and 6 μM or above (white), with grey representing no interaction. (TIF 13895 kb)