Verschuuren, Marlies Verstraelen, Peter García-Díaz Barriga, Gerardo Cilissen, Ines Coninx, Emma Verslegers, Mieke Larsen, Peter H. Nuydens, Rony Vos, Winnok Additional file 10: of High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity Figure S9. Classification of morphological data confirms findings based on connectivity score. A RFC that was trained on pooled DMSO treated cultures revealed a negative impact of rapamycin on neuronal connectivity as can be seen from the cultures that were misclassified and were assigned a culture age that was lower than the actual culture age (red). Treatment with 0.01 μM and 0.1 μM of GNE3511 could however improve the neuronal connectivity (green) (nbio = 3 x ntech = 5 except for GNE3511: nbio = 2 x ntech = 6). (PDF 10993 kb) Neuronal connectivity;Neuronal network;Synapse;Calcium imaging;High-content screening;Neurodegeneration;Antioxidant depletion;hTau.P301L 2019-06-04
    https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_of_High-throughput_microscopy_exposes_a_pharmacological_window_in_which_dual_leucine_zipper_kinase_inhibition_preserves_neuronal_network_connectivity/8228147
10.6084/m9.figshare.8228147.v1