10.6084/m9.figshare.8228147.v1 Marlies Verschuuren Marlies Verschuuren Peter Verstraelen Peter Verstraelen Gerardo García-Díaz Barriga Gerardo García-Díaz Barriga Ines Cilissen Ines Cilissen Emma Coninx Emma Coninx Mieke Verslegers Mieke Verslegers Peter H. Larsen Peter H. Larsen Rony Nuydens Rony Nuydens Winnok Vos Winnok Vos Additional file 10: of High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity Springer Nature 2019 Neuronal connectivity Neuronal network Synapse Calcium imaging High-content screening Neurodegeneration Antioxidant depletion hTau.P301L 2019-06-04 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_of_High-throughput_microscopy_exposes_a_pharmacological_window_in_which_dual_leucine_zipper_kinase_inhibition_preserves_neuronal_network_connectivity/8228147 Figure S9. Classification of morphological data confirms findings based on connectivity score. A RFC that was trained on pooled DMSO treated cultures revealed a negative impact of rapamycin on neuronal connectivity as can be seen from the cultures that were misclassified and were assigned a culture age that was lower than the actual culture age (red). Treatment with 0.01 μM and 0.1 μM of GNE3511 could however improve the neuronal connectivity (green) (nbio = 3 x ntech = 5 except for GNE3511: nbio = 2 x ntech = 6). (PDF 10993 kb)