10.6084/m9.figshare.8228147.v1
Marlies Verschuuren
Marlies
Verschuuren
Peter Verstraelen
Peter
Verstraelen
Gerardo García-Díaz Barriga
Gerardo
García-Díaz Barriga
Ines Cilissen
Ines
Cilissen
Emma Coninx
Emma
Coninx
Mieke Verslegers
Mieke
Verslegers
Peter H. Larsen
Peter H.
Larsen
Rony Nuydens
Rony
Nuydens
Winnok Vos
Winnok
Vos
Additional file 10: of High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity
Springer Nature
2019
Neuronal connectivity
Neuronal network
Synapse
Calcium imaging
High-content screening
Neurodegeneration
Antioxidant depletion
hTau.P301L
2019-06-04 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_of_High-throughput_microscopy_exposes_a_pharmacological_window_in_which_dual_leucine_zipper_kinase_inhibition_preserves_neuronal_network_connectivity/8228147
Figure S9. Classification of morphological data confirms findings based on connectivity score. A RFC that was trained on pooled DMSO treated cultures revealed a negative impact of rapamycin on neuronal connectivity as can be seen from the cultures that were misclassified and were assigned a culture age that was lower than the actual culture age (red). Treatment with 0.01 μM and 0.1 μM of GNE3511 could however improve the neuronal connectivity (green) (nbio = 3 x ntech = 5 except for GNE3511: nbio = 2 x ntech = 6). (PDF 10993 kb)