Additional file 1: of Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development Sandra Prieto Cassandra Reed Haley James Kyle Quinn Timothy Muldoon 10.6084/m9.figshare.8105660.v1 https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Differences_in_colonic_crypt_morphology_of_spontaneous_and_colitis-associated_murine_models_via_second_harmonic_generation_imaging_to_quantify_colon_cancer_development/8105660 Supplementary Information. Contains additional details on the optimization of automated crypt detection sensitivity, the method for selecting quantifiable image features, the method for image segmentation and quantification of crypt structures, as well as additional results of image segmentation and quantification of crypt structures and image depth stack results. (DOCX 5593 kb) 2019-05-09 05:00:00 Colorectal cancer Inflammatory bowel disease Multiphoton Second harmonic generation Image analysis Crypt morphology Azoxymethane Dextran sulfate sodium salt