Additional file 6 of Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells Irma Mitre-Aguilar Tonatiuh Barrios-Garcia Victor Ruiz-Lopez Alberto Cabrera-Quintero Nancy Mejia-Dominguez Jose Ventura-Gallegos Daniel Moreno-Mitre Alejandro Aranda-Gutierrez Janini Mejia-Rangel Alma Escalona-Guzman Yanin Chavarri-Guerra Alfonso Leon-Del-Rio Alejandro Zentella-Dehesa 10.6084/m9.figshare.7997360.v1 https://springernature.figshare.com/articles/journal_contribution/Additional_file_6_of_Glucocorticoid-dependent_expression_of_IAP_participates_in_the_protection_against_TNF-mediated_cytotoxicity_in_MCF7_cells/7997360 siRNA against c-IAP1 or XIAP decreased the cytotoxic protection of GCs. Values represent the % viability at 18 h post-treatment. MOCK: Transfection without siRNA. NR-siRNA: Transfection with nonrelated siRNA. c-IAP1-siRNA: Transitory transfection with siRNA targeting c-IAP1 transcripts. XIAP-siRNA: Transitory transfection with siRNA targeting c-XIAP transcripts. The siRNAs selected for this experiment resulted in the lowest expression of their target IAP (as shown in Fig. 6) (*): Represents the % loss of protection in cells with siRNA-mediated inhibited c-IAP1 and XIAP vs cells treated with CORT + TNF + NR-siRNA or DEX + TNF + NR-siRNA. (DOCX 130 kb) 2019-04-15 05:00:00 Cell death Glucocorticoid receptor Glucocorticoids Inhibitor of apoptosis proteins Tumor necrosis factor MCF7 cells