10.6084/m9.figshare.7981193.v1 Terje Sundstrøm Terje Sundstrøm Lars Prestegarden Lars Prestegarden Francisco Azuaje Francisco Azuaje Synnøve Aasen Synnøve Aasen Gro Røsland Gro Røsland Jobin Varughese Jobin Varughese Marzieh Bahador Marzieh Bahador Simon Bernatz Simon Bernatz Yannick Braun Yannick Braun Patrick Harter Patrick Harter Kai Skaftnesmo Kai Skaftnesmo Elizabeth Ingham Elizabeth Ingham Lisa Mahakian Lisa Mahakian Sarah Tam Sarah Tam Clifford Tepper Clifford Tepper Kjell Petersen Kjell Petersen Katherine Ferrara Katherine Ferrara Karl Tronstad Karl Tronstad Morten Lund-Johansen Morten Lund-Johansen Rudi Beschorner Rudi Beschorner Rolf Bjerkvig Rolf Bjerkvig Frits Thorsen Frits Thorsen Additional file 8: of Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis Springer Nature 2019 Cancer Melanoma Brain metastasis BRAF V600E β-Sitosterol Treatment 2019-04-10 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_8_of_Inhibition_of_mitochondrial_respiration_prevents_BRAF-mutant_melanoma_brain_metastasis/7981193 Figure S7. a Functional classification of the brain metastasis gene signature. Human biological processes (metabolic processes are highlighted in red), and b signaling pathways associated with the 108-gene brain metastasis signature using the Protein Analysis Through Evolutionary Relationships (PANTHER) classification system. c Known and predicted protein interactions of β-sitosterol from the Search Tool for Interactions of Chemicals (STITCH 4.0). Green lines represent direct interactions with β-sitosterol whereas blue lines represent protein-protein interactions. Direct activation (green arrows) or inhibition (red lines) is indicated. d Significant statistical associations of β-sitosterol targets with cellular processes predicted with the Human Experimental/Functional Mapper (HEFalMp). P-values represent approximate multiple hypothesis corrected values. (TIF 1333 kb)