10.6084/m9.figshare.7981193.v1
Terje Sundstrøm
Terje
Sundstrøm
Lars Prestegarden
Lars
Prestegarden
Francisco Azuaje
Francisco
Azuaje
Synnøve Aasen
Synnøve
Aasen
Gro Røsland
Gro
Røsland
Jobin Varughese
Jobin
Varughese
Marzieh Bahador
Marzieh
Bahador
Simon Bernatz
Simon
Bernatz
Yannick Braun
Yannick
Braun
Patrick Harter
Patrick
Harter
Kai Skaftnesmo
Kai
Skaftnesmo
Elizabeth Ingham
Elizabeth
Ingham
Lisa Mahakian
Lisa
Mahakian
Sarah Tam
Sarah
Tam
Clifford Tepper
Clifford
Tepper
Kjell Petersen
Kjell
Petersen
Katherine Ferrara
Katherine
Ferrara
Karl Tronstad
Karl
Tronstad
Morten Lund-Johansen
Morten
Lund-Johansen
Rudi Beschorner
Rudi
Beschorner
Rolf Bjerkvig
Rolf
Bjerkvig
Frits Thorsen
Frits
Thorsen
Additional file 8: of Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Springer Nature
2019
Cancer
Melanoma
Brain metastasis
BRAF V600E
β-Sitosterol
Treatment
2019-04-10 05:00:00
Figure
https://springernature.figshare.com/articles/figure/Additional_file_8_of_Inhibition_of_mitochondrial_respiration_prevents_BRAF-mutant_melanoma_brain_metastasis/7981193
Figure S7. a Functional classification of the brain metastasis gene signature. Human biological processes (metabolic processes are highlighted in red), and b signaling pathways associated with the 108-gene brain metastasis signature using the Protein Analysis Through Evolutionary Relationships (PANTHER) classification system. c Known and predicted protein interactions of β-sitosterol from the Search Tool for Interactions of Chemicals (STITCH 4.0). Green lines represent direct interactions with β-sitosterol whereas blue lines represent protein-protein interactions. Direct activation (green arrows) or inhibition (red lines) is indicated. d Significant statistical associations of β-sitosterol targets with cellular processes predicted with the Human Experimental/Functional Mapper (HEFalMp). P-values represent approximate multiple hypothesis corrected values. (TIF 1333 kb)