10.6084/m9.figshare.7975229.v1
Gianandrea Traversi
Gianandrea
Traversi
David Staid
David
Staid
Mario Fiore
Mario
Fiore
Zulema Percario
Zulema
Percario
Daniela Trisciuoglio
Daniela
Trisciuoglio
Roberto Antonioletti
Roberto
Antonioletti
Veronica Morea
Veronica
Morea
Francesca Degrassi
Francesca
Degrassi
Renata Cozzi
Renata
Cozzi
MOESM6 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin
Springer Nature
2019
Resveratrol analogues
Tubulin polymerization
Cancer cell proliferation
Centrosome fragmentation
γ-tubulin
2019-04-10 05:00:00
Figure
https://springernature.figshare.com/articles/figure/MOESM6_of_A_novel_resveratrol_derivative_induces_mitotic_arrest_centrosome_fragmentation_and_cancer_cell_death_by_inhibiting_-tubulin/7975229
Additional file 6: Figure S6. Chemical structure of the intermediate and final products of the synthesis of 3,5,4′-TMS and 3,4,4′-TMS. 3,5,4′-TMS (5a) and 3,4,4′-TMS (5b) were synthetized by the classical synthesis of olefins using Wittig reaction with a slight modification. The ylide was generated by LiOH starting from the phosphonium salt (2). Then, the olefin products were obtained as mixture of cis and trans isomers by reaction with benzaldehydes 3a or 3b. The Z/E mixtures (4) were converted to the E-isomers 5a and 5b by heating with catalytic amounts of iodine in refluxing heptane.