Additional file 5: of HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis Frederike Riemslagh Hannes Lans Harro Seelaar Lies-Anne Severijnen Shamiram Melhem Wim Vermeulen Eleonora Aronica R. Pasterkamp John Swieten Rob Willemsen 10.6084/m9.figshare.7843106.v1 https://springernature.figshare.com/articles/journal_contribution/Additional_file_5_of_HR23B_pathology_preferentially_co-localizes_with_p62_pTDP-43_and_poly-GA_in_C9ORF72-linked_frontotemporal_dementia_and_amyotrophic_lateral_sclerosis/7843106 Figure S5. HR23B pathology in different brain areas of C9FTD cases. Staining of HR23B in several brain areas of C9FTD cases and non-demented controls. Pathology burden was highest in cortices (frontal, temporal and motor) and was mostly cytoplasmic (inclusions and neuropils) and intranuclear (cateye). Hippocampus dentate gyrus (DG) harbors perinuclear inclusions, and hippocampus cornu ammonis (CA) had some cells with strong nuclear staining. Pathology was low in cerebellum granular layer with only some nuclear and perinuclear inclusions and almost absent in cerebellum molecular layer. Our C9FTD cases did not show HR23B pathology in spinal cord neurons. All scale bars are 20 μm (PDF 2260 kb) 2019-03-13 05:00:00 C9ORF72 ALS FTD HR23B ERAD NGly1 DPRs Poly-GA