MOESM8 of The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression KidoTatsuo LauYun-Fai 2019 Additional file 8: Figure S4. Small molecule inhibitors for CDC25 and RRM2, the downstream pro-oncogenic molecules of TSPY, inhibited cell proliferation in hepatocellular carcinoma cell line HuH-7.