Additional file 2: of Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis
Yingxia Ning
Weifeng Feng
Xiaocheng Cao
Kaiqun Ren
Meifang Quan
A. Chen
Chang Xu
Yebei Qiu
Jianguo Cao
Xiang Li
Xin Luo
10.6084/m9.figshare.7592558.v1
https://springernature.figshare.com/articles/figure/Additional_file_2_of_Genistein_inhibits_stemness_of_SKOV3_cells_induced_by_macrophages_co-cultured_with_ovarian_cancer_stem-like_cells_through_IL-8_STAT3_axis/7592558
Figure S2. GEN alleviated stemness of SKOV3 cells induced by Co-CM. OVCAR-3 cells treated with Co-CM from the co-culture of OVCAR-3-derived OCSLCs with THP-1 macrophages and were treated with or without different concentrations of GEN (10, 20, and 40 μM). The sphere and colony formation rate (A and B, scale bar, 100 μm) and expression levels of CD133 and CD44 (C) as well as Nanog and Oct4 (D) in OVCAR-3 cells were shown.*P < 0.05, vs OVCAR-3 cells induced by co-culture were treated with vehicle (0.1% DMSO). #P < 0.05, vs OVCAR-3 cells induced by co-culture treated with GEN (10.0 μM). These experiments were performed in triplicate. (TIF 24203 kb)
2019-01-15 05:00:00
Ovarian cancer
Tumor associated macrophages
Ovarian cancer stem-like cells
Genistein
IL-8/STAT3 axis