Kan, Chen Ding, Na Yang, Jiazhao Tan, Zhenya McGuire, Tammy Lu, Haimei Zhang, Keqin Berger, Diana Kessler, John Kan, Lixin Additional file 13: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC niche) is composed of niche-dwelling progenitor/stem cells (including at least Tie2-cre, Gli1-creER and Glast-creERT labeled cells) and niche supportive cells (including mast cells, neurites, vasculature and macrophages). The formation of the MSC niche likely initiates the pathological osteogenic cascade, under the co-regulation of BMP and Hh signaling through feedback and non-cell autonomous mechanisms. (TIF 1825 kb) Heterotopic ossification (HO);Niche;Mesenchymal stem cells (MSCs);Niche supportive cells;Niche supportive molecules;Bone morphogenetic protein (BMP);Hedgehog (Hh) 2019-01-11
    https://springernature.figshare.com/articles/figure/Additional_file_13_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581170
10.6084/m9.figshare.7581170.v1