Additional file 4: of Comparative genomics analysis to differentiate metabolic and virulence gene potential in gastric versus enterohepatic Helicobacter species MannionAnthony ShenZeli FoxJames 2018 Figure S4. Expanded diagram of amino acids biosynthesis pathways reconstructed in Helicobacter genomes. Enzymes are labeled in boxes with their enzyme code (E.C.) or gene abbreviations and solid arrows showing their reactions. Dashed arrows indicate multi-enzyme reactions to different biosynthetic pathways. Abbreviations: alanine (Ala), arginine (Arg), asparagine (Asn), aspartic acid (Asp), cysteine (Cys), glutamic acid (Glu), glutamine (Gln), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), methionine (Met), phenylalanine (Phe), proline (Pro), serine (Ser), threonine (Thr), tryptophan (Trp), tyrosine (Tyr), valine (Val), non-oxidative pentose phosphate pathway (PPP), asparaginase (AnsB), aspartate aminotransferase (AspB), gamma-glutamyltranspeptidase (GGT), proline dehydrogenase (PutA), serine dehydratase (SdaA), 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), phosphoribosyl pyrophosphate (PRPP), erythrose 4-phosphate (E4P), glycerate-3P (3PG), phosphoenolpyruvate (PEP), pyruvate (Pyr), oxaloacetate (Oxa). (JPG 334 kb)