10.6084/m9.figshare.7210595.v1 Kelly Ceyzériat Kelly Ceyzériat Lucile Ben Haim Lucile Ben Haim Audrey Denizot Audrey Denizot Dylan Pommier Dylan Pommier Marco Matos Marco Matos Océane Guillemaud Océane Guillemaud Marie-Ange Palomares Marie-Ange Palomares Laurene Abjean Laurene Abjean Fanny Petit Fanny Petit Pauline Gipchtein Pauline Gipchtein Marie-Claude Gaillard Marie-Claude Gaillard Martine Guillermier Martine Guillermier Sueva Bernier Sueva Bernier Mylène Gaudin Mylène Gaudin Gwenaëlle Aurégan Gwenaëlle Aurégan Charlène Joséphine Charlène Joséphine Nathalie Déchamps Nathalie Déchamps Julien Veran Julien Veran Valentin Langlais Valentin Langlais Karine Cambon Karine Cambon Alexis Bemelmans Alexis Bemelmans Jan Baijer Jan Baijer Gilles Bonvento Gilles Bonvento Marc Dhenain Marc Dhenain Jean-François Deleuze Jean-François Deleuze Stéphane Oliet Stéphane Oliet Emmanuel Brouillet Emmanuel Brouillet Philippe Hantraye Philippe Hantraye Maria-Angeles Carrillo-de Sauvage Maria-Angeles Carrillo-de Sauvage Robert Olaso Robert Olaso Aude Panatier Aude Panatier Carole Escartin Carole Escartin Additional file 1: of Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease Springer Nature 2018 Reactive astrocytes Alzheimer’s disease JAK2-STAT3 pathway Signaling cascades Viral vectors Neuroinflammation Mouse models 2018-10-16 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_1_of_Modulation_of_astrocyte_reactivity_improves_functional_deficits_in_mouse_models_of_Alzheimer_s_disease/7210595 Figure S1. AAV infect astrocytes selectively. To validate astrocyte tropism of the AAVs used in our study, an AAV2/9 encoding GFP was injected in the hippocampus of WT mice. GFP+ cells co-express the astrocytic marker GFAP and S100β, but not NeuN, IBA1, Olig2 and MBP, which are markers of neurons, microglial cells, cells of the oligodendrocyte lineage and myelinating oligodendrocytes, respectively. Astrocyte tropism of these vectors was confirmed in AD mice as well (See colocalization of GFP with GFAP in Figs. 1b and S2). (TIF 14477 kb)