Dataset containing genotype data for single nucleotide polymorphism markers in sporadic breast cancer related genes in a Sri Lankan case-control cohort of postmenopausal women SirisenaNirmala Dushyanthi SamaranayakeNilakshi DissanayakeVajira H.W. 2019 <p></p><p>This dataset consists of three Excel spreadsheets in .xlsx format, containing the raw genotype data of a study which investigated the association of single nucleotide polymorphisms (SNPs) in breast cancer related genes with the risk and clinicopathological profiles of sporadic breast cancer among Sri Lankan postmenopausal women.</p><p> </p><p>A case-control study design was adopted to conduct SNP marker disease association testing using single variant and haplotype association testing strategies in an existing blood resource obtained from a cohort of Sri Lankan postmenopausal women with clinically phenotyped sporadic breast cancer and healthy controls. The list of haplotype-tagging SNP markers for genotyping was selected based on the information available in the published literature and the use of bioinformatics tools and databases.</p><p> </p><p>During the study, 350 Sri Lankan postmenopausal women with histopathologically confirmed invasive breast cancer (cases), and 350 healthy postmenopausal women (controls) were genotyped for 57 haplotype-tagging single nucleotide polymorphisms (SNPs) in 36 candidate genes associated with sporadic breast cancer using the iPLEX Sequenom Mass-Array platform.</p><p> </p><p>The dataset contains the following files:</p><p> </p><p><b>Data file 1_Genotypes_cases.xlsx</b> consists of a single spreadsheet, containing the raw genotype data for the 57 SNPs in the 350 postmenopausal women with sporadic breast cancer (cases).</p><p> </p><p><b>Data file 2_Genotypes_controls.xlsx </b>consists of a single spreadsheet, containing raw genotype data for the 57 SNPs for 350 healthy postmenopausal women (controls).</p><p> </p><p><b>Datafile 3_Primer Sequences </b>consists of a single spreadsheet, containing the primer sequences used to amplify each of the 57 SNPs.</p><p> </p><p> </p><p>The <b>.xlsx</b> files can be opened using Microsoft Excel or any open spreadsheet software.</p><p></p>