10.6084/m9.figshare.6838580.v1
Loïc Dayon
Loïc
Dayon
Antonio Núñez Galindo
Antonio
Núñez Galindo
Jérôme Wojcik
Jérôme
Wojcik
Ornella Cominetti
Ornella
Cominetti
John Corthésy
John
Corthésy
Aikaterini Oikonomidi
Aikaterini
Oikonomidi
Hugues Henry
Hugues
Henry
Martin Kussmann
Martin
Kussmann
Eugenia Migliavacca
Eugenia
Migliavacca
India Severin
India
Severin
Gene Bowman
Gene
Bowman
Julius Popp
Julius
Popp
Additional file 1: Supplementary Methods. of Alzheimer disease pathology and the cerebrospinal fluid proteome
Springer Nature
2018
Alzheimer disease
Amyloid
Biomarker
Cerebrospinal fluid
CSF
Mass spectrometry
Proteomics
Tau
Tandem mass tag
2018-07-18 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Supplementary_Methods_of_Alzheimer_disease_pathology_and_the_cerebrospinal_fluid_proteome/6838580
Table S1. Demographics and clinical characteristics of subjects removed from the statistical analyses. Table S2. Non-AD versus AD CSF biomarker profile group comparison after selection in all subjects of 26 proteins with LASSO. Table S3. Non-AD versus AD CSF biomarker profile group comparison after selection in subjects with cognitive impairment of 18 proteins with LASSO. Table S4. Correlation of CSF proteins with CSF Aβ1-42. Table S5. Correlation of CSF proteins with CSF tau. Table S6. Correlation of CSF proteins with CSF P-tau181. Table S7. Group comparisons of CSF protein measurements for AD versus non-AD CSF biomarker profiles in all subjects. Table S8. Group comparisons of CSF protein measurements for AD versus non-AD CSF biomarker profiles in subjects with cognitive impairment. Figure S1. Box-plots of CSF proteins (selected with LASSO analyses) for positive and negative CSF profiles of AD pathology in all subjects and subjects with cognitive impairment. Figure S2. Pairwise correlation heatmap of the 26 CSF proteins selected with LASSO for classification of non-AD versus AD CSF biomarker profiles for all subjects. Figure S3. Pairwise correlation heatmap of the 18 CSF proteins selected with LASSO for classification of non-AD versus AD CSF biomarker profiles for subjects with cognitive impairment. Figure S4. Correlations of CSF neurogranin and neuromodulin with CSF tau and P-tau181. Figure S5. Chord diagram of the relationships of 59 CSF proteins with CSF tau, P-tau181, and/or Aβ1-42. Figure S6. Venn diagrams of CSF proteins with significant group comparison differences between AD versus non-AD CSF biomarker profiles and those correlating with CSF Aβ1-42, tau, and P-tau181. Figure S7. Venn diagrams of CSF proteins selected with LASSO to classify non-AD versus AD CSF biomarker profiles and those correlating with CSF Aβ1-42, tau, and P-tau181. (DOCX 2575 kb)