Pereira, Mariana Buongermino Wallroth, Mikael Jonsson, Viktor Kristiansson, Erik Additional file 1 of Comparison of normalization methods for the analysis of metagenomic gene abundance data Figure S1. Histograms of Spearman correlations between normalization factors and raw counts of non-differentially abundant genes (non-DAGs). Spearman correlations were compute per gene in the Human gut I, for group size 10+10, with 10% of effects divided equally between the two group, and fold-change 3. Affected genes were randomly selected in 100 iterations. The following methods are included in the figure trimmed mean of M-values (TMM), relative log expression (RLE), cumulative sum scaling (CSS), reversed cumulative sum scaling (RCSS), upper quartile (UQ), median (Med) and total count (TC). (PDF 76 kb) Shotgun metagenomics;Gene abundances;Normalization;High-dimensional data;Systematic variability;False discovery rate 2018-04-20
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10.6084/m9.figshare.6168440.v1