Additional file 1: of Open-label, randomized multicentre phase II study to assess the efficacy and tolerability of sunitinib by dose administration regimen (dose modification or dose interruptions) in patients with advanced or metastatic renal cell carcinoma: study protocol of the SURF trial MouilletGuillaume PaillardMarie-Justine MaurinaTristan VernereyDewi Nguyen Tan HonThierry AlmotlakHamadi SteinUlrich CalcagnoFabien BerthodDiane RobertElise MeurisseAurelia Thiery-VuilleminAntoine 2018 SPIRIT checklist. (DOC 122 kb)