Additional file 1: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis KawaguchiHoshimi MatsumotoIsao OsadaAtsumu KurataIzumi EbeHiroshi TanakaYuki InoueAsuka UmedaNaoto KondoYuya TsuboiHiroto ShinkaiYasuhiro KumagaiYoshito IshigamiAkihito SumidaTakayuki 2018 Figure S1. DBA/1 mice were immunized with pGPI. (a) The clinical score (mean ± SEM) of pGIA (n = 11). (b) Sera were obtained once per week between days 0 and 28 from pGIA and control mice. The titers of anti-CCP antibodies were analyzed by ELISA (n = 12–18). Each symbol represents a single mouse, and the horizontal and vertical bars represent the mean and SEM values, respectively. *p < 0.05, **p < 0.01. (TIFF 120 kb)