MOESM4 of CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus PengRan WangYe FengWan-wan YueXin-jing ChenJiang-he HuXiao-zhuang LiZhi-feng ShengDuo-hong ZhangYou-ming LiYue-zhong 2018 Additional file 4: Figure S4. The sequence and expression vector of sgRNA. The promoter of pilA gene (shown in orange color) from M. xanthus drives transcription of sgRNAs. The sgRNA fragment containing the 20-nt specific targeting sequence (green), the tracrRNA scaffold (blue) and the human U6 terminator (red).