10.6084/m9.figshare.5768856.v1 Laura MacConaill Laura MacConaill Robert Burns Robert Burns Anwesha Nag Anwesha Nag Haley Coleman Haley Coleman Michael Slevin Michael Slevin Kristina Giorda Kristina Giorda Madelyn Light Madelyn Light Kevin Lai Kevin Lai Mirna Jarosz Mirna Jarosz Matthew McNeill Matthew McNeill Matthew Ducar Matthew Ducar Matthew Meyerson Matthew Meyerson Aaron Thorner Aaron Thorner Additional file 3: Figure S3. of Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing Springer Nature 2018 Next generation sequencing Massively parallel sequencing Adapter Index Barcode cross-talk Illumina Multiplexing UMI Molecular barcode 2018-01-08 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_3_Figure_S3_of_Unique_dual-indexed_sequencing_adapters_with_UMIs_effectively_eliminate_index_cross-talk_and_significantly_improve_sensitivity_of_massively_parallel_sequencing/5768856 Schematic of the sources of sample cross-talk including adapter contamination, index hopping during multiplex target enrichment post-capture PCR, index hopping during cluster amplification, and demultiplexing errors. Unique dual-matched indices reduce read misassignment because unexpected index combinations are removed from downstream analysis. (PDF 936 kb)