10.6084/m9.figshare.5768856.v1
Laura MacConaill
Laura
MacConaill
Robert Burns
Robert
Burns
Anwesha Nag
Anwesha
Nag
Haley Coleman
Haley
Coleman
Michael Slevin
Michael
Slevin
Kristina Giorda
Kristina
Giorda
Madelyn Light
Madelyn
Light
Kevin Lai
Kevin
Lai
Mirna Jarosz
Mirna
Jarosz
Matthew McNeill
Matthew
McNeill
Matthew Ducar
Matthew
Ducar
Matthew Meyerson
Matthew
Meyerson
Aaron Thorner
Aaron
Thorner
Additional file 3: Figure S3. of Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing
Springer Nature
2018
Next generation sequencing
Massively parallel sequencing
Adapter
Index
Barcode cross-talk
Illumina
Multiplexing
UMI
Molecular barcode
2018-01-08 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_3_Figure_S3_of_Unique_dual-indexed_sequencing_adapters_with_UMIs_effectively_eliminate_index_cross-talk_and_significantly_improve_sensitivity_of_massively_parallel_sequencing/5768856
Schematic of the sources of sample cross-talk including adapter contamination, index hopping during multiplex target enrichment post-capture PCR, index hopping during cluster amplification, and demultiplexing errors. Unique dual-matched indices reduce read misassignment because unexpected index combinations are removed from downstream analysis. (PDF 936 kb)