%0 Figure %A Duneau, David %A Kondolf, Hannah %A Im, Joo %A Ortiz, Gerardo %A Chow, Christopher %A Fox, Michael %A Eugénio, Ana %A Revah, J. %A Buchon, Nicolas %A Lazzaro, Brian %D 2017 %T Additional file 6: Figure S6. of The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila %U https://springernature.figshare.com/articles/figure/Additional_file_6_Figure_S6_of_The_Toll_pathway_underlies_host_sexual_dimorphism_in_resistance_to_both_Gram-negative_and_Gram-positive_bacteria_in_mated_Drosophila/5728791 %R 10.6084/m9.figshare.5728791.v1 %2 https://springernature.figshare.com/ndownloader/files/10075395 %K Sexual dimorphism %K Innate immunity %K Antimicrobial peptides %K Drosophila melanogaster %K Toll pathway %X Sexual dimorphism of the Toll pathway. (A) Survival of male and female with downregulation of modSP (da-Gal4 > modSP-RNAi), of psh (da-Gal4 > psh-RNAi) or of wildtype (da-Gal4 > Canton S). We confirmed via RNA interference that psh but not modSP was responsible for the sexual dimorphism in survival upon P. rettgeri infection (Cox-ph: Line (psh vs. Canton S): df = 1, χ2 = 0.22, P = 0.63, Sex: df = 1, χ2 = 13.97, P = 0.0002, Line*Sex: df = 1, χ2 = 0.73, P = 0.4; Cox-ph: Line (modSP vs. Canton S): df = 1, χ2 = 2.14, P = 0.14, Sex: df = 1, χ2 = 8.18, P = 0.004, Line*Sex: df = 1, χ2 = 4.23, P = 0.04). (B) Relative expression of Drosomycin to RpL32 in both sexes 24 and 72 h after the injection of PBS or of P. rettgeri. Toll response (i.e., difference in Drosomycin expression between PBS and infected) was stronger in male than in females at 72 h (Interaction Sex x Treatment: df = 1, F = 10.64, P = 0.006) but we did not detect a difference at 24 h post-injection (Interaction Sex x Treatment: df = 1, F = 2.53, P = 0.13). (TIF 180 kb) %I figshare