%0 Figure %A Chagani, Sharmeen %A Wang, Rong %A Carpenter, Evan %A Löhr, Christiane %A Ganguli-Indra, Gitali %A Indra, Arup %D 2017 %T Additional file 1: Figure S1. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas %U https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Ablation_of_epidermal_RXR_in_cooperation_with_activated_CDK4_and_oncogenic_NRAS_generates_spontaneous_and_acute_neonatal_UVB_induced_malignant_metastatic_melanomas/5589520 %R 10.6084/m9.figshare.c.3926998_D1.v1 %2 https://springernature.figshare.com/ndownloader/files/9720547 %K Keratinocytes %K Melanocytes %K Acute UVB %K Retinoid-X-receptor α (RXRα) %K Malignant melanoma %K Trigenic %K Spontaneous melanoma %K NRASQ61K %K CDK4R24C/R24C %K Microenvironment %X Breeding of mouse lines and UV scheme used in this study. (a) Breeding crossings used. K14-Cretg/O I RxrαL2/L2 is also known as Rxrαep−/−. (b) Scheme for single neonatal UVB treatment of mice. (c) H&E stained section showing poorly differentiated melanoma with abnormally large nuclei compared to the normal range (inset). (TIFF 1999 kb) %I figshare