Additional file 1: Figure S1. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas Sharmeen Chagani Rong Wang Evan Carpenter Christiane Löhr Gitali Ganguli-Indra Arup Indra 10.6084/m9.figshare.c.3926998_D1.v1 https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Ablation_of_epidermal_RXR_in_cooperation_with_activated_CDK4_and_oncogenic_NRAS_generates_spontaneous_and_acute_neonatal_UVB_induced_malignant_metastatic_melanomas/5589520 Breeding of mouse lines and UV scheme used in this study. (a) Breeding crossings used. K14-Cretg/O I RxrαL2/L2 is also known as Rxrαep−/−. (b) Scheme for single neonatal UVB treatment of mice. (c) H&E stained section showing poorly differentiated melanoma with abnormally large nuclei compared to the normal range (inset). (TIFF 1999 kb) 2017-11-09 05:00:00 Keratinocytes Melanocytes Acute UVB Retinoid-X-receptor α (RXRα) Malignant melanoma Trigenic Spontaneous melanoma NRASQ61K CDK4R24C/R24C Microenvironment