10.6084/m9.figshare.c.3869137_D6.v1 Vir Patel Vir Patel John Capra John Capra Additional file 6: of Ancient human miRNAs are more likely to have broad functions and disease associations than young miRNAs Springer Nature 2017 miRNA evolution Human disease Phylogenetics Gene regulation 2017-08-31 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_6_of_Ancient_human_miRNAs_are_more_likely_to_have_broad_functions_and_disease_associations_than_young_miRNAs/5368333 The number of miRNAs annotated in a species is significantly correlated with the percentage of young miRNAs in the species. Over 146 species, we observed a Spearman’s correlation of 0.68 (P = 4.1e–06) between the number of annotated miRNAs and the percentage of young miRNAs in the species. This relationship is likely the result of limitations in current knowledge of miRNA sequences and annotations. In this analysis, young miRNAs were defined as those younger than 25 % of the overall age range. See Additional file 1 for the list of all species considered and miRNA counts. (PDF 15 kb)