Additional file 4 of Choice of futility boundaries for group sequential designs with two endpoints
Svenja Schüler
Meinhard Kieser
Geraldine Rauch
10.6084/m9.figshare.c.3846742_D4.v1
https://springernature.figshare.com/articles/Additional_file_4_of_Choice_of_futility_boundaries_for_group_sequential_designs_with_two_endpoints/5287804
Probability of stopping for futility and overall power for Approach 3. Plot of probability of stopping for futility (left figure) and overall power (right figure) for Approach 3 using the futility β γ-boundaries α f CE = 0.69 $ \alpha_{f}^{CE}=0.69$ and α f MC = 0.65 $ \alpha_{f}^{MC}=0.65$ for composite endpoint and main component, respectively. (JPG 202 kb)
2017-08-08 05:00:00
Group sequential design
Stopping for futility
Two endpoints
Intersection-union test