%0 Figure %A Esanov, Rustam %A Cabrera, Gabriela %A Andrade, Nadja %A Gendron, Tania %A Brown, Robert %A Benatar, Michael %A Wahlestedt, Claes %A Mueller, Christian %A Zeier, Zane %D 2017 %T Additional file 3: Figure S3. of A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD %U https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S3_of_A_C9ORF72_BAC_mouse_model_recapitulates_key_epigenetic_perturbations_of_ALS_FTD/5104102 %R 10.6084/m9.figshare.c.3801571_D3.v1 %2 https://springernature.figshare.com/ndownloader/files/8662822 %K Amyotrophic lateral sclerosis %K C9ORF72 BAC mouse %K Induced pluripotent stem cells %K DNA methylation %K Hydroxymethylation %K R-loops %X Linear regression analysis of the mean C9ORF72 promoter methylation percentile (as determined by bisulfite pyrosequencing) and glycine-proline dipeptide abundance (A). R square and p values for individual CpG dinucleotides are indicated (B). Quantitative PCR assessment of C9ORF72 expression in hypermethylated C9-BAC mice indicated by open shapes (17wks square, 30wks triangle, 36wks circle) and their age group counterparts (C), error bars represent SEM. (JPEG 530 kb) %I figshare