10.6084/m9.figshare.c.3758096_D5.v1
Franc Llorens
Franc
Llorens
Katrin Thüne
Katrin
Thüne
Beata Sikorska
Beata
Sikorska
Matthias Schmitz
Matthias
Schmitz
Waqas Tahir
Waqas
Tahir
Natalia Fernández-Borges
Natalia
Fernández-Borges
Maria Cramm
Maria
Cramm
Nadine Gotzmann
Nadine
Gotzmann
Margarita Carmona
Margarita
Carmona
Nathalie Streichenberger
Nathalie
Streichenberger
Uwe Michel
Uwe
Michel
Saima Zafar
Saima
Zafar
Anna-Lena Schuetz
Anna-Lena
Schuetz
Ashish Rajput
Ashish
Rajput
Olivier Andréoletti
Olivier
Andréoletti
Stefan Bonn
Stefan
Bonn
Andre Fischer
Andre
Fischer
Pawel Liberski
Pawel
Liberski
Juan Torres
Juan
Torres
Isidre Ferrer
Isidre
Ferrer
Inga Zerr
Inga
Zerr
Additional file 5: Figure S4. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease
Springer Nature
2017
Creutzfeldt-Jakob disease
Prion protein
Calpain
Cathepsin
Calcium
Ca2+
2017-04-27 05:00:00
Presentation
https://springernature.figshare.com/articles/presentation/Additional_file_5_Figure_S4_of_Altered_Ca2_homeostasis_induces_Calpain-Cathepsin_axis_activation_in_sporadic_Creutzfeldt-Jakob_disease/4929173
Alteration of autophagy related genes in sCJD. (A) Altered expression of genes involved in autophagy in the cortex of the tg340-PRNP129MM mice at 120 (pre-clinical) and 180 (clinical) days after inoculation with sCJD MM1 brain homogenates. (B) qPCR analysis of the autophagy activators hspa8 and hspb8 in the sCJD infected tg340-PRNP129MM mice at 180 dpi. (C) Western.-blot and densitometric analysis of the autophagy related proteins DJ-1, LC3, ATG5 and LAMP2 in the frontal cortex of control and sCJD MM1 and sCJD VV2 cases. (D) qPCR analysis of the autophagy-related genes HSPA8, HSPB8, PARK (DJ-1) and LAMP2 in the frontal cortex of control and sCJD MM1 and sCJDVV2 cases. Unpaired t-test (95% CI) was used for the comparisons of the two groups. ANOVA test followed by post-test Tukey’s Multiple Comparison Test was used to compare the values from different groups. P values for the comparisons of the three groups are indicated in the figure:*p < 0.05; **p < 0.01; ***p < 0.001. (PPTX 244 kb)