Additional file 3: Figure S2. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease Franc Llorens Katrin Thüne Beata Sikorska Matthias Schmitz Waqas Tahir Natalia Fernández-Borges Maria Cramm Nadine Gotzmann Margarita Carmona Nathalie Streichenberger Uwe Michel Saima Zafar Anna-Lena Schuetz Ashish Rajput Olivier Andréoletti Stefan Bonn Andre Fischer Pawel Liberski Juan Torres Isidre Ferrer Inga Zerr 10.6084/m9.figshare.c.3758096_D3.v1 https://springernature.figshare.com/articles/presentation/Additional_file_3_Figure_S2_of_Altered_Ca2_homeostasis_induces_Calpain-Cathepsin_axis_activation_in_sporadic_Creutzfeldt-Jakob_disease/4929128 ER stress in the frontal cortex of sCJD cases. ER stress and Ca2+ induced genes in sCJD MM1 by (A) Western-blot (grp78, hsp27, BDNF, Fas and Bcl-2) and (B) Bcl-2/Bax ratio in the frontal cortex of control and sCJD MM1 cases obtained from the densitometric analysis of both proteins detected by western-blot analysis. Unpaired t-test (95% CI) was used for the comparisons of the two groups. *p < 0.05; **p < 0.01; ***p < 0.001. (PPTX 130 kb) 2017-04-27 05:00:00 Creutzfeldt-Jakob disease Prion protein Calpain Cathepsin Calcium Ca2+