10.6084/m9.figshare.c.3743315_D1.v1
Todd Knutson
Todd
Knutson
Thu Truong
Thu
Truong
Shihong Ma
Shihong
Ma
Nicholas Brady
Nicholas
Brady
Megan Sullivan
Megan
Sullivan
Ganesh Raj
Ganesh
Raj
Kathryn Schwertfeger
Kathryn
Schwertfeger
Carol Lange
Carol
Lange
Additional file 1: of Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs
Springer Nature
2017
Progesterone receptor (PR)
Phosphorylation
ERK/MAP kinase (MAPK)
SUMOylation
Antiprogestin
Onapristone
Estrogen receptor (ER)
Breast cancer
RUNX2
Cancer stem cells
2017-04-17 05:00:00
Dataset
https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Posttranslationally_modified_progesterone_receptors_direct_ligand-specific_expression_of_breast_cancer_stem_cell-associated_gene_programs/4880108
Gene sets derived from T47D cells expressing WT PR and KR PR. These gene sets were used in the analysis described in Fig. 5c, d. (A) 16 genes were discovered to be highly upregulated by progestin in cells expressing KR PR, compared to WT PR. These genes were also not regulated by other PR ligands. (B) 101 genes were discovered to be highly upregulated by progestin in cells expressing WT PR, compared to KR PR. These genes were also not regulated by other PR ligands. (XLSX 28 kb)