10.6084/m9.figshare.c.3723067_D2.v1
Michal Arbel-Ornath
Michal
Arbel-Ornath
Eloise Hudry
Eloise
Hudry
Josiah Boivin
Josiah
Boivin
Tadafumi Hashimoto
Tadafumi
Hashimoto
Shuko Takeda
Shuko
Takeda
Kishore Kuchibhotla
Kishore
Kuchibhotla
Steven Hou
Steven
Hou
Carli Lattarulo
Carli
Lattarulo
Arianna Belcher
Arianna
Belcher
Naomi Shakerdge
Naomi
Shakerdge
Pariss Trujillo
Pariss
Trujillo
Alona Muzikansky
Alona
Muzikansky
Rebecca Betensky
Rebecca
Betensky
Bradley Hyman
Bradley
Hyman
Brian Bacskai
Brian
Bacskai
Additional file 2: Figure S2. of Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain
Springer Nature
2017
Alzheimer’s disease
Amyloid β oligomers
Calcium
In vivo imaging
2017-03-21 05:00:00
Figure
https://springernature.figshare.com/articles/figure/Additional_file_2_Figure_S2_of_Soluble_oligomeric_amyloid-_induces_calcium_dyshomeostasis_that_precedes_synapse_loss_in_the_living_mouse_brain/4776169
Time course of oAβ-induced increase in resting calcium levels after acute exposure with TgCM on a healthy brain. C57BL/6 mice were injected with AAV-CBA-YC3.6 into the somatosensory cortex and acutely exposed to TgCM containing oAβ. The changes in YFP/CFP ratios in the neurites were measured at baseline before treatment and 30 min, 1 h and 5 h after topical application of TgCM. A progressive increase in the levels of resting calcium (YFP/CFP ratio and the actual calcium levels on the lower and upper x-axis, respectively) was detected that reached a peak after 1 h (20.6% of overloaded neurites), before returning to baseline levels after 5 h (1.7% overloaded neurites). (TIF 37844 kb)