Kumar, Dilip Puan, Kia Andiappan, Anand Lee, Bernett Westerlaken, Geertje Haase, Doreen Melchiotti, Rossella Li, Zhuang Yusof, Nurhashikin Lum, Josephine Koh, Geraldine Foo, Shihui Yeong, Joe Alves, Alexessander Pekkanen, Juha Sun, Liang Irwanto, Astrid Fairfax, Benjamin Naranbhai, Vivek Common, John Tang, Mark Chuang, Chin Jarvelin, Marjo-Riitta Knight, Julian Zhang, Xuejun Chew, Fook Prabhakar, Shyam Jianjun, Liu Yun Wang, De Zolezzi, Francesca Poidinger, Michael Lane, E. Meyaard, Linde Rötzschke, Olaf Additional file 8: of A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus Model on the potentiating effect of a regulatory CpG-SNP. A Conventional vs. regulatory CpG-SNPs. The methylation of CpG pairs results in the condensation of chromatin due to a tighter packaging of the histone-DNA complexes (open circle: non-methylated CpG, closed circle: methylated CpG). While a conventional CpG-SNP can assist this process by providing only one additional allele-dependent methylation site (middle panel), a regulatory CpG-SNP (such as rs612529) modulates the recruiting of CpG-modifying enzymes (right panel). In the case of rs612529, this seems to be mediated by the allele-specific binding of PU.1 to the T allele of the CpG-SNP. In monocytes PU.1 was reported to bind the demethylase Tet-2. B Potentiating effect. Recruitment of Tet-2 mediates the chromatin-opening by facilitating the demethylation of all CpG pairs in the vicinity. The epigenetic effect is allele-specific (T allele) and direction of the direction probably cell-type–dependent. (PDF 415 kb) VSTM1;Signal inhibitory receptor on leukocytes-1 (SIRL-1);Expression quantitative trait loci (eQTL);Atopic dermatitis;Monocytes;Reactive oxygen species (ROS);Neutrophils 2017-02-20
    https://springernature.figshare.com/articles/journal_contribution/Additional_file_8_of_A_functional_SNP_associated_with_atopic_dermatitis_controls_cell_type-specific_methylation_of_the_VSTM1_gene_locus/4670119
10.6084/m9.figshare.c.3696271_D8.v1