10.6084/m9.figshare.c.3663442_D2.v1
Zsigmond Benko
Zsigmond
Benko
Dong Liang
Dong
Liang
Ge Li
Ge
Li
Robert Elder
Robert
Elder
Anindya Sarkar
Anindya
Sarkar
Jun Takayama
Jun
Takayama
Arun Ghosh
Arun
Ghosh
Richard Zhao
Richard
Zhao
MOESM1 of A fission yeast cell-based system for multidrug resistant HIV-1 proteases
Springer Nature
2017
HIV-1
Multidrug resistant proteases
Fission yeast
Proteolytic cleavage
Cell proliferation
Oxidative stress
Mitochondria
Cell death
Protease inhibitors
2017-01-11 05:00:00
Presentation
https://springernature.figshare.com/articles/presentation/MOESM1_of_A_fission_yeast_cell-based_system_for_multidrug_resistant_HIV-1_proteases/4541938
Additional file 1: Figure S1. DRV and its derivatives suppress the M7PR but not the M10PR or M11PR over time. The chemical structures of protease inhibitors, DRV, UIC-94003, GRL-0489A, GRL-0249A, GRL-0159A and GRL-044-10A are shown in (Fig. 4A). All six compounds including DRV are P2 ligands [17]. Effects of the newly synthesized protease inhibitors on mdrPR-induced growth arrest were measured against the wtPR and mdrPRs by using a liquid growth assay and measured by OD650 over a time period from 16 to 72 h after the drug treatments and gene inductions. The final drug concentration of 200 µM was used in each of the experiments. DRV was used here as a positive control and no drug treatment was used as a negative control.