Additional file 2: Figure S1. of Early evolutionary history and genomic features of gene duplicates in the human genome BuLijing KatjuVaishali 2015 Decrease in the frequency of intrachromosomal duplicates with K S in three age-cohorts. Figure S2. The physical distance between intrachromosomal paralogs as a function of K S . Figure S3. Duplication span of DNA- and RNA-mediated duplicates as a function of K S . Figure S4. Transcriptional orientation (direct versus inverse) of intrachromosomal duplicates within three age-cohorts. Figure S5. Frequencies of three structural categories of DNA-mediated gene duplicates across three age-cohorts. Figure S6. Box plot displaying the distribution of minimum duplication span for young gene duplicates. (PDF 303 kb)