Additional file 3: Figure S2. of Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
Marcelo Ezquer
Cristhian Urzua
Scarleth Montecino
Karla Leal
Paulette Conget
Fernando Ezquer
10.6084/m9.figshare.c.3644633_D4.v1
https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S2_of_Intravitreal_administration_of_multipotent_mesenchymal_stromal_cells_triggers_a_cytoprotective_microenvironment_in_the_retina_of_diabetic_mice/4469528
MSC administration does not modify the apoptotic rate in the retina of DM mice. Apoptosis in the retina was analyzed by the TUNEL technique in serial 4-μm eye sections 4 weeks after MSC administration (A) and 12 weeks after MSC administration (B). Nuclei were counterstained with DAPI. Arrows indicate TUNEL-positive cells. The number of apoptotic nuclei was quantified at both experimental times and expressed as fold-change versus normal mice (C and D). Qualitative data are representative of eight eyes per analyzed time. Quantitative data correspond to mean ± SEM of eight eyes per group and per analyzed time. (PNG 3862 kb)
2016-03-16 05:00:00
Diabetes
Diabetic retinopathy
Multipotent mesenchymal stromal cells
Mesenchymal stem cells
Microenvironment
Cytoprotection
Retinal ganglion cells
Prevention