10.6084/m9.figshare.c.3642281_D8.v1
Matthew Care
Matthew
Care
David Westhead
David
Westhead
Reuben Tooze
Reuben
Tooze
Additional file 2: Figure S2. of Gene expression meta-analysis reveals immune response convergence on the IFNÎł-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma
Springer Nature
2015
DLBCL
PDF 1658 kb
gene signature
IFN Îł-STAT axis
GCB-DLBCL
ontology enrichments
COO-unclassified
CU
Gene expression meta-analysis
ABC-DLBCL
2015-09-11 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_2_Figure_S2_of_Gene_expression_meta-analysis_reveals_immune_response_convergence_on_the_IFN_-STAT1-IRF1_axis_and_adaptive_immune_resistance_mechanisms_in_lymphoma/4461848
Outline of the process for integrating and visualizing analysis of gene signature and ontology enrichments. The flow diagram illustrates the process for integrating gene signature and ontology enrichments. The initial assessment of overlap between meta-profiles derived from the comparison of ABC-DLBCL versus COO-unclassified (CU) DLBCL and GCB-DLBCL versus COO-unclassified (CU) DLBCL is shown at the top of the figure, followed by the parallel analysis of gene ontology (BiNGO) and hypergeometric testing of signature enrichments. Next a matrix is illustrated showing the occurrence of genes versus enriched signatures (green fill), followed by analysis of correlations (Phi coefficient) by column (signature/ontology terms) or by row (genes) and hierarchical clustering. (PDF 1658 kb)