Additional file 10: Figure S5. of Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types Tenghui Chen Zixing Wang Wanding Zhou Zechen Chong Funda Meric-Bernstam Gordon Mills Ken Chen 10.6084/m9.figshare.c.3634619_D3.v1 https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_Figure_S5_of_Hotspot_mutations_delineating_diverse_mutational_signatures_and_biological_utilities_across_cancer_types/4435886 Functional implications of hotspot mutations in RNA and protein expression. In OV, tumor samples with missense hotspot mutations (I195, Y220, R248 and R273) in TP53 show higher TP53 RNA and protein expression than those with non-hotspot mutations and without TP53 mutations. * indicates p < 0.05 and ** indicates p < 0.001 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 and ## indicates p < 0.001 between samples with specified hotspot mutations and samples without mutations in examined gene. (PDF 365 kb) 2016-06-23 05:00:00 sample TP 53 show cancer types Functional implications TP 53 mutations TP 53 RNA PDF 365 kb hotspot mutations missense hotspot mutations protein expression OV non-hotspot mutations