Additional file 10: Figure S5. of Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types
Tenghui Chen
Zixing Wang
Wanding Zhou
Zechen Chong
Funda Meric-Bernstam
Gordon Mills
Ken Chen
10.6084/m9.figshare.c.3634619_D3.v1
https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_Figure_S5_of_Hotspot_mutations_delineating_diverse_mutational_signatures_and_biological_utilities_across_cancer_types/4435886
Functional implications of hotspot mutations in RNA and protein expression. In OV, tumor samples with missense hotspot mutations (I195, Y220, R248 and R273) in TP53 show higher TP53 RNA and protein expression than those with non-hotspot mutations and without TP53 mutations. * indicates p < 0.05 and ** indicates p < 0.001 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 and ## indicates p < 0.001 between samples with specified hotspot mutations and samples without mutations in examined gene. (PDF 365 kb)
2016-06-23 05:00:00
sample
TP 53 show
cancer types Functional implications
TP 53 mutations
TP 53 RNA
PDF 365 kb
hotspot mutations
missense hotspot mutations
protein expression
OV
non-hotspot mutations