%0 Journal Article %A Habano, Wataru %A Kawamura, Kohei %A Iizuka, Natsuki %A Terashima, Jun %A Sugai, Tamotsu %A Ozawa, Shogo %D 2015 %T Additional file 3: Figure S3. of Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes %U https://springernature.figshare.com/articles/journal_contribution/Additional_file_3_Figure_S3_of_Analysis_of_DNA_methylation_landscape_reveals_the_roles_of_DNA_methylation_in_the_regulation_of_drug_metabolizing_enzymes/4422341 %R 10.6084/m9.figshare.c.3630488_D7.v1 %2 https://springernature.figshare.com/ndownloader/files/7148987 %K DNA methylation mapping %K Differences in drug metabolism %K Integrative analysis %K Alternative splicing %X Representative results of correlation analysis. Significant inverse correlations between DNA methylation levels and mRNA expression levels were detected for the other five DME genes (CYP1A2, CYP2D6, GSTM5, GSTT1, and SULT1A1; p < 0.05, Spearman’s rank correlation test). The mRNA expression level, shown as the vertical axis, was normalized to the level of ACTB mRNA (set as 100 %). CpG sites with significant correlation are indicated by asterisks in the methylation map for each gene. CpG sites showing β R values of more than 0.296 are indicated by circles. (PDF 54.3 KB) %I figshare