10.6084/m9.figshare.c.3626939_D16.v1 Andrew Keniry Andrew Keniry Linden Gearing Linden Gearing Natasha Jansz Natasha Jansz Joy Liu Joy Liu Aliaksei Holik Aliaksei Holik Peter Hickey Peter Hickey Sarah Kinkel Sarah Kinkel Darcy Moore Darcy Moore Kelsey Breslin Kelsey Breslin Kelan Chen Kelan Chen Ruijie Liu Ruijie Liu Catherine Phillips Catherine Phillips Miha Pakusch Miha Pakusch Christine Biben Christine Biben Julie Sheridan Julie Sheridan Benjamin Kile Benjamin Kile Catherine Carmichael Catherine Carmichael Matthew Ritchie Matthew Ritchie Douglas Hilton Douglas Hilton Marnie Blewitt Marnie Blewitt MOESM10 of Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing Springer Nature 2016 H3K9 methylation X inactivation Epigenetic silencing Setdb1 2016-05-18 05:00:00 Figure https://springernature.figshare.com/articles/figure/MOESM10_of_Setdb1-mediated_H3K9_methylation_is_enriched_on_the_inactive_X_and_plays_a_role_in_its_epigenetic_silencing/4411847 Additional file 10. DNA methylation is largely unaltered upon Setdb1 depletion outside of X-linked CpG islandseRRBS data from Setdb1 +/+ Xist ∆A/+ 129/CAST transduced with Nons (Female) or Setdb1 +/gt Xist ∆A/+ 129/CAST transduced with shSetdb1.6 (Setdb1 depleted) MEFs, showing mC for individual CpGs on the Xa and Xi in Female (n = 3) and Setdb1 depleted female samples (n = 2), for CpGs outside CGIs on the X chromosome (Student’s two-tailed t-test) as log2(mC/C) (a), within CGIs on autosomes (b), outside CGIs on autosomes (c) and within CGIs with greater than 20% mC on autosomes (d). Note that autosomal data used is not allele specific. Dotted line indicates median for Xi in Female.