%0 Figure %A Burm, Saskia %A Peferoen, Laura %A Zuiderwijk-Sick, Ella %A Haanstra, Krista %A ‘t Hart, Bert %A van der Valk, Paul %A Amor, Sandra %A Bauer, Jan %A Bajramovic, Jeffrey %D 2016 %T Additional file 1: Figure S1 of Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself %U https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Expression_of_IL-1_in_rhesus_EAE_and_MS_lesions_is_mainly_induced_in_the_CNS_itself/4396058 %R 10.6084/m9.figshare.c.3621767_D1.v1 %2 https://springernature.figshare.com/ndownloader/files/7122428 %K Multiple sclerosis %K Experimental autoimmune encephalomyelitis %K Inflammasome %K IL-1β %K Microglia %K Preactive lesion %X Activation status of IL-1β+ cells in the rim of chronic active lesions. IL-1β+ cells in the rim of chronic active lesions were double stained for IL-1β (in brown) and cell surface markers associated with pro-inflammatory or anti-inflammatory cellular phenotypes (in red). IL-1β staining colocalized with MHC class II (a) and with CD74 (b), although we also observed some IL-1β+/CD74− cells. Furthermore, IL-1β staining colocalized with CD40 (c), CD200R (d), and CCL22 (e), although we also observed some IL-1β+/CCL22− cells. IL-1β and MR staining were both observed in rim of chronic active lesions (f), but all IL-1β+ cells were MR−. Original magnifications ×40, scale bar represents 50 μm. Nuclei were counterstained with hematoxylin (blue). (TIF 7190 kb) %I figshare