%0 Figure %A I. J. Young, Adelaide %A Law, Andrew %A Castillo, Lesley %A Chong, Sabrina %A Cullen, Hayley %A Koehler, Martin %A Herzog, Sebastian %A Brummer, Tilman %A Lee, Erinna %A Fairlie, Walter %A Lucas, Morghan %A Herrmann, David %A Allam, Amr %A Timpson, Paul %A Watkins, D. %A Millar, Ewan %A O’Toole, Sandra %A Gallego-Ortega, David %A Ormandy, Christopher %A Oakes, Samantha %D 2016 %T Additional file 3: Figure S2. of MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib %U https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S2_of_MCL-1_inhibition_provides_a_new_way_to_suppress_breast_cancer_metastasis_and_increase_sensitivity_to_dasatinib/4391567 %R 10.6084/m9.figshare.c.3620204_D3.v1 %2 https://springernature.figshare.com/ndownloader/files/7117901 %K Myeloid cell leukemia-1 %K BIMs2A %K Metastasis %K Invasion %K Breast cancer %K BH3 mimetics %K Cofilin %K SRC family kinase %X showing the apoptotic effect of MCL-1 siRNA and MCL-1 inhibitors on MDA-MB-468-2A and MDA-MB-231-2A, MDA-MB-157 and HCC-1937 cells. (A) MCL-1 siRNA. Bar graphs depicting the average fraction of apoptotic cells, measured as total Annexin V-positive by flow cytometry, for cells and treatments as indicated at 48 hours. Error bars show standard error of the mean. (B) MCL-1 inhibitors. Bar graphs of apoptosis as measured in (A) for cells and treatments as indicated. For A1210477 and UMI-77: + treated with 5 μM, ++ treated with 10 μM. All graphs are the average of three independent experiments. Bars indicate statistically significant groups, p value unpaired t tests. (JPG 1192 kb) %I figshare