I. J. Young, Adelaide Law, Andrew Castillo, Lesley Chong, Sabrina Cullen, Hayley Koehler, Martin Herzog, Sebastian Brummer, Tilman Lee, Erinna Fairlie, Walter Lucas, Morghan Herrmann, David Allam, Amr Timpson, Paul Watkins, D. Millar, Ewan O’Toole, Sandra Gallego-Ortega, David Ormandy, Christopher Oakes, Samantha Additional file 6: Figure S6. of MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib showing that MCL-1 antagonism and Dasatinib treatment induced apoptosis in MDA-MB-468-2A cells but not MDA-MB-231-2A cells when grown in 2D monolayer cultures. Bar graphs depicting the average fraction of apoptotic cells (total Annexin V-positive by flow cytometry) as indicated after 24 hours after treatment with vehicle, DOX, 5 μM A1210477 and 5 μM UMI-77 alone and in combination with 1 μM dasatinib after 24 hours. All graphs and western blots are the average of three independent experiments. Bars indicate statistically significant groups, p value paired t tests. (JPG 1029 kb) Myeloid cell leukemia-1;BIMs2A;Metastasis;Invasion;Breast cancer;BH3 mimetics;Cofilin;SRC family kinase 2016-12-08
    https://springernature.figshare.com/articles/figure/Additional_file_6_Figure_S6_of_MCL-1_inhibition_provides_a_new_way_to_suppress_breast_cancer_metastasis_and_increase_sensitivity_to_dasatinib/4391552
10.6084/m9.figshare.c.3620204_D2.v1