10.6084/m9.figshare.c.3618236_D2.v1
Su Lim
Su
Lim
Won Choi
Won
Choi
Ki-Wook Oh
Ki-Wook
Oh
Yuanchao Xue
Yuanchao
Xue
Ji Choi
Ji
Choi
Sung Kim
Sung
Kim
Minyeop Nahm
Minyeop
Nahm
Young-Eun Kim
Young-Eun
Kim
Jinhyuk Lee
Jinhyuk
Lee
Min-Young Noh
Min-Young
Noh
Seungbok Lee
Seungbok
Lee
Sejin Hwang
Sejin
Hwang
Chang-Seok Ki
Chang-Seok
Ki
Xiang-Dong Fu
Xiang-Dong
Fu
Seung Kim
Seung
Kim
Additional file 1: Figure S1. of Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis
Springer Nature
2016
Amyotrophic lateral sclerosis
Fused in sarcoma
Human cell models
Induced neuron
Nuclear localization signal
Stress granules
Neuronal cytoplasmic inclusion
2016-01-22 05:00:00
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Figure_S1_of_Directly_converted_patient-specific_induced_neurons_mirror_the_neuropathology_of_FUS_with_disrupted_nuclear_localization_in_amyotrophic_lateral_sclerosis/4385120
Structures of FUS-Transportin-1 complexes. (a) Overall structure of FUS-Transportin-1 complexes are presented in blue sphere and white surface, respectively. The position of FUS (p.Q519) is marked by red sphere models. (b) The focused view around the mutation (p.Q519). The structure of FUS and Transportin-1 complexes are consisted of a ball-and-stick representation. Stick models are colored by atom (N: blue, O: red, C: gray, respectively). The important position of the mutation (p.Q519) is depicted in a red ball-and-stick representation. A possible hydrogen bonding between Q519 of FUS and E509 of Transportin-1 is shown in the red circle with the acceptor-donor distance (3.21Â Ă
). (PDF 69Â kb)