10.6084/m9.figshare.c.3618236_D2.v1 Su Lim Su Lim Won Choi Won Choi Ki-Wook Oh Ki-Wook Oh Yuanchao Xue Yuanchao Xue Ji Choi Ji Choi Sung Kim Sung Kim Minyeop Nahm Minyeop Nahm Young-Eun Kim Young-Eun Kim Jinhyuk Lee Jinhyuk Lee Min-Young Noh Min-Young Noh Seungbok Lee Seungbok Lee Sejin Hwang Sejin Hwang Chang-Seok Ki Chang-Seok Ki Xiang-Dong Fu Xiang-Dong Fu Seung Kim Seung Kim Additional file 1: Figure S1. of Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis Springer Nature 2016 Amyotrophic lateral sclerosis Fused in sarcoma Human cell models Induced neuron Nuclear localization signal Stress granules Neuronal cytoplasmic inclusion 2016-01-22 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Figure_S1_of_Directly_converted_patient-specific_induced_neurons_mirror_the_neuropathology_of_FUS_with_disrupted_nuclear_localization_in_amyotrophic_lateral_sclerosis/4385120 Structures of FUS-Transportin-1 complexes. (a) Overall structure of FUS-Transportin-1 complexes are presented in blue sphere and white surface, respectively. The position of FUS (p.Q519) is marked by red sphere models. (b) The focused view around the mutation (p.Q519). The structure of FUS and Transportin-1 complexes are consisted of a ball-and-stick representation. Stick models are colored by atom (N: blue, O: red, C: gray, respectively). The important position of the mutation (p.Q519) is depicted in a red ball-and-stick representation. A possible hydrogen bonding between Q519 of FUS and E509 of Transportin-1 is shown in the red circle with the acceptor-donor distance (3.21 Å). (PDF 69 kb)