%0 Figure %A Achariyar, Thiyagaragan %A Li, Baoman %A Peng, Weiguo %A Verghese, Philip %A Shi, Yang %A McConnell, Evan %A Benraiss, Abdellatif %A Kasper, Tristan %A Song, Wei %A Takana, Takahiro %A Holtzman, David %A Nedergaard, Maiken %A Deane, Rashid %D 2016 %T Additional file 3: Figure S3. of Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation %U https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S3_of_Glymphatic_distribution_of_CSF-derived_apoE_into_brain_is_isoform_specific_and_suppressed_during_sleep_deprivation/4381997 %R 10.6084/m9.figshare.c.3617204_D11.v1 %2 https://springernature.figshare.com/ndownloader/files/7108157 %K Glymphatic pathways %K AQP4 %K Alzheimer’s disease %K Lymphatic system %K Brain clearance %K Sleep/wake %X Radial distribution around arteries is greater for non-lipidated than lapidated apoE4. A-H) Representative images (from 3 to 4 mice) of radial diffusion of non-lipidated (A-D) and lipidated apoE4-Alexa647 that was colored green (E-H) at 10 min after their intracisternal injection in NG2ds-Red (NG2, red) reporter mice. The vasculature was outlined by intravascular labeling with lectin (colored blue). Scale bar = 100 μm. I) Clearance of 125I-apoE3 and 125I-apoE4 (10 nM) 90 min after their intracortical injection (0.5 μL over 5 min). J) FITC-apoE3 (10 nM) or 125I-apoE3 (10 nM) ISF clearance were similar 90 min after their intracortical injection. Values are mean ± SEM, n = 5-6 mice. (EPS 26205 kb) %I figshare