10.6084/m9.figshare.c.3617204_D11.v1
Thiyagaragan Achariyar
Thiyagaragan
Achariyar
Baoman Li
Baoman
Li
Weiguo Peng
Weiguo
Peng
Philip Verghese
Philip
Verghese
Yang Shi
Yang
Shi
Evan McConnell
Evan
McConnell
Abdellatif Benraiss
Abdellatif
Benraiss
Tristan Kasper
Tristan
Kasper
Wei Song
Wei
Song
Takahiro Takana
Takahiro
Takana
David Holtzman
David
Holtzman
Maiken Nedergaard
Maiken
Nedergaard
Rashid Deane
Rashid
Deane
Additional file 3: Figure S3. of Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation
Springer Nature
2016
Glymphatic pathways
AQP4
Alzheimer’s disease
Lymphatic system
Brain clearance
Sleep/wake
2016-12-08 05:00:00
Figure
https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S3_of_Glymphatic_distribution_of_CSF-derived_apoE_into_brain_is_isoform_specific_and_suppressed_during_sleep_deprivation/4381997
Radial distribution around arteries is greater for non-lipidated than lapidated apoE4. A-H) Representative images (from 3 to 4 mice) of radial diffusion of non-lipidated (A-D) and lipidated apoE4-Alexa647 that was colored green (E-H) at 10 min after their intracisternal injection in NG2ds-Red (NG2, red) reporter mice. The vasculature was outlined by intravascular labeling with lectin (colored blue). Scale bar = 100 μm. I) Clearance of 125I-apoE3 and 125I-apoE4 (10 nM) 90 min after their intracortical injection (0.5 μL over 5 min). J) FITC-apoE3 (10 nM) or 125I-apoE3 (10 nM) ISF clearance were similar 90 min after their intracortical injection. Values are mean ± SEM, n = 5-6 mice. (EPS 26205 kb)