10.6084/m9.figshare.c.3617204_D11.v1 Thiyagaragan Achariyar Thiyagaragan Achariyar Baoman Li Baoman Li Weiguo Peng Weiguo Peng Philip Verghese Philip Verghese Yang Shi Yang Shi Evan McConnell Evan McConnell Abdellatif Benraiss Abdellatif Benraiss Tristan Kasper Tristan Kasper Wei Song Wei Song Takahiro Takana Takahiro Takana David Holtzman David Holtzman Maiken Nedergaard Maiken Nedergaard Rashid Deane Rashid Deane Additional file 3: Figure S3. of Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation Springer Nature 2016 Glymphatic pathways AQP4 Alzheimer’s disease Lymphatic system Brain clearance Sleep/wake 2016-12-08 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S3_of_Glymphatic_distribution_of_CSF-derived_apoE_into_brain_is_isoform_specific_and_suppressed_during_sleep_deprivation/4381997 Radial distribution around arteries is greater for non-lipidated than lapidated apoE4. A-H) Representative images (from 3 to 4 mice) of radial diffusion of non-lipidated (A-D) and lipidated apoE4-Alexa647 that was colored green (E-H) at 10 min after their intracisternal injection in NG2ds-Red (NG2, red) reporter mice. The vasculature was outlined by intravascular labeling with lectin (colored blue). Scale bar = 100 μm. I) Clearance of 125I-apoE3 and 125I-apoE4 (10 nM) 90 min after their intracortical injection (0.5 μL over 5 min). J) FITC-apoE3 (10 nM) or 125I-apoE3 (10 nM) ISF clearance were similar 90 min after their intracortical injection. Values are mean ± SEM, n = 5-6 mice. (EPS 26205 kb)