Additional file 1: Figure S1. of PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma
Xi-wen Bi
Hua Wang
Wen-wen Zhang
Jing-hua Wang
Wen-jian Liu
Zhong-jun Xia
Hui-qiang Huang
Wen-qi Jiang
Yu-jing Zhang
Liang Wang
10.6084/m9.figshare.c.3615515_D2.v1
https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_PD-L1_is_upregulated_by_EBV-driven_LMP1_through_NF-_B_pathway_and_correlates_with_poor_prognosis_in_natural_killer_T-cell_lymphoma/4376672
PD-L1 was upregulated in SNK-6 cells through MAPK/NF-κB pathway. (A) The expression level of p-Raf-B, Raf-B, p-p38, p38, p-JNK, JNK, p-ERK, ERK, p65, and PD-L1 in SNK-6 cells or SNK-6 cells treated with 0.1 μM SB590885, a selective B-Raf inhibitor for 1 h. (B) The expression level of p-ERK, ERK, p65, and PD-L1 in SNK-6 cells or SNK-6 cells treated with 20 μM PD98059, a selective ERK inhibitor for 1 h. (C) The expression level of p-p38, p38, p65, and PD-L1 in SNK-6 cells or SNK-6 cells treated with 10 μM SB203580, a selective p38 inhibitor for 1 h. (D) The expression level of p-JNK, JNK, p65, and PD-L1 in SNK-6 cells or SNK-6 cells treated with 20 μM SP600125, a selective JNK inhibitor for 1 h. (E) The expression level of p65 and PD-L1 in SNK-6 cells or SNK-6 cells treated with 100 μM pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-κB for 1 h. (TIF 1305 kb)
2016-10-13 05:00:00
Natural killer/T-cell lymphoma
Latent membrane protein 1
Epstein–Barr virus
Programmed cell death receptor 1