Additional file 3: of Deltex1 is inhibited by the NotchâHairy/E(Spl) signaling pathway and induces neuronal and glial differentiation
Yi-Chuan Cheng
Yin-Cheng Huang
Tu-Hsueh Yeh
Hung-Yu Shih
Ching-Yu Lin
Sheng-Jia Lin
Ching-Chi Chiu
Ching-Wen Huang
Yun-Jin Jiang
10.6084/m9.figshare.c.3612536_D6.v1
https://springernature.figshare.com/articles/figure/Additional_file_3_of_Deltex1_is_inhibited_by_the_Notch_Hairy_E_Spl_signaling_pathway_and_induces_neuronal_and_glial_differentiation/4367240
Disruption of Dtx1 expression had no effects on neuronal proliferation and apoptosis. a. Proliferating neurons were double-labeled with phospho-histone H3 antibody (brown) and neurogenin1 riboprobes (purple). Apoptotic neuronal precursor cells were labeled for neurogenin1 (fluorescent green) and activated caspase-3 antibody (fluorescent red). b. Proliferating neuronal cells were quantified by counting the proportions of phospho-histone H3- and neurogenin1-positive cells, whereas apoptotic neural progenitor cells were quantified by counting the proportions of activated caspase-3- and neurogenin1-positive cells, revealing no marked differences between the embryos injected with dtx1 full , dtx1 morpholinos, and the controls. n.s., nonsignificant. (TIF 2461Â kb)
2015-12-30 05:00:00
Dtx1
Neural differentiation
Notch
Hairy/E(Spl)
Zebrafish