Additional file 13: of Development and clinical application of an integrative genomic approach to personalized cancer therapy
Andrew Uzilov
Wei Ding
Marc Fink
Yevgeniy Antipin
Andrew Brohl
Claire Davis
Chun Lau
Chetanya Pandya
Hardik Shah
Yumi Kasai
James Powell
Mark Micchelli
Rafael Castellanos
Zhongyang Zhang
Michael Linderman
Yayoi Kinoshita
Micol Zweig
Katie Raustad
Kakit Cheung
Diane Castillo
Melissa Wooten
Imane Bourzgui
Leah Newman
Gintaras Deikus
Bino Mathew
Jun Zhu
Benjamin Glicksberg
Aye Moe
Jun Liao
Lisa Edelmann
Joel Dudley
Robert Maki
Andrew Kasarskis
Randall Holcombe
Milind Mahajan
Ke Hao
Boris Reva
Janina Longtine
Daniela Starcevic
Robert Sebra
Michael Donovan
Shuyu Li
Eric Schadt
Rong Chen
10.6084/m9.figshare.c.3605855_D12.v1
https://springernature.figshare.com/articles/dataset/Additional_file_13_of_Development_and_clinical_application_of_an_integrative_genomic_approach_to_personalized_cancer_therapy/4346954
A gzipped tarball (.tgz file) of VCF files containing somatic mutations (i.e. present exclusively in tumor) for the 25 patients (one VCF file per patient) on whom paired normal/tumor WES was carried out and whose consents permitted public release of the full variant call data. For patients where multiple assays were carried out (WGS, WES, targeted panel, PacBio validation for troubleshooting), the VCF file contains the final variant call set where any discordance amongst the assays was resolved. Only mutations altering amino acid sequence (missense, nonsense, canonical splice site, indel) in a canonical isoform of a gene are given. Mutations are included that are not explicitly reported in returned findings due to lack of known relevance to cancer. Mutations rejected during our manual review protocol are not included. Thus, VCFs may contain mutations that were not manually reviewed. Three patients (P0009, P0025, and P0040) have two tumor specimens available, therefore those VCFs are multi-sample and report which mutations are recurrent among tumors and which are not; the rest are single-sample. (ZIP 37 kb)
2016-06-01 05:00:00
Cancer
Genomics
Personalized medicine
Clinical application