%0 Figure %A Song, Guohe %A Xu, Shifeng %A Zhang, Hong %A Wang, Yupeng %A Xiao, Chao %A Jiang, Tao %A Wu, Leilei %A Zhang, Tao %A Sun, Xing %A Zhong, Lin %A Zhou, Chongzhi %A Wang, Zhaowen %A Peng, Zhihai %A Chen, Jian %A Wang, Xiaoliang %D 2016 %T Additional file 3: Figure S3. of TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway %U https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S3_of_TIMP1_is_a_prognostic_marker_for_the_progression_and_metastasis_of_colon_cancer_through_FAK-PI3K_AKT_and_MAPK_pathway/4329923 %R 10.6084/m9.figshare.c.3600176_D1.v1 %2 https://springernature.figshare.com/ndownloader/files/7053578 %K TIMP1 %K Colon cancer %K Prognosis %K Tumorigenesis %X Schematic representation for the TIMP1 regulatory pathway proposed in this study. TIMP1 activates FAK/PI3K-AKT and MAPK pathway, which facilitated AKT/ERK phosphorylation. This promotes the activation of BAD, cyclin D1, P21, P27 and other Transcription substrates, leading to potentiation of cell antiapoptosis, proliferation and invasion in CRC. (TIF 903 kb) %I figshare