Metadata associated with the published article: Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes ParejaFresia PaulaArnaud Da Cruz Gularte-MéridaRodrigo VahdatiniaMahsa LiAnqi GeyerFelipe C. SilvaEdaise M. da NanjangudGouri WenHannah Y. VargaZsuzsanna BrogiEdi RakhaEmad A. WeigeltBritta Reis-FilhoJorge S. 2020 <p><b>Summary</b></p><p>This metadata record describes the data generated and analysed in the published article “Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes”. The data include histologic images, RNA sequencing, Archer FusionPlex sequencing, Sanger sequencing and Fluorescence in situ hybridization data.</p><p></p><p>The study which generated the data described here investigated whether primary pleomorphic adenomas (PAs) and mucoepidermoid carcinomas (MECs) of the breast would be underpinned by the fusion genes reported to occur in their salivary gland counterparts. </p><p><br></p><p><b>Data description and access</b></p><ul><li><p>Histologic images: These support figures 1, 2 and 3. They are in <b>.jpg</b> format and can be requested from Dr. Fresia Pareja.</p></li><li><p>RNA sequencing data (PAs, n=2; MEC, n=1): These support figures 1, 2 and 3, and supplementary tables 1 and 2. They are in <b>BAM </b>format, and are openly available from NCBI Sequence Read Archive under the project accession number SRP257886. The project contains three experiments, with accession numbers: SRX8155358, SRX8155357 and SRX8155356. The identifiers.org link to the project is <a href="https://identifiers.org/ncbi/insdc.sra:SRP257886">https://identifiers.org/ncbi/insdc.sra:SRP257886</a></p></li><li><p>Archer FusionPlex sequencing data (PA, n=1): These support figures 1 and 2, and supplementary tables 1 and 2. They are in Archer FusionPlex sequencing <b>BAM </b>format and can be requested from Dr. Da Cruz Paula.</p></li><li><p>Fluorescence in situ hybridization data: These support figures 1, 2 and 3. They are in <b>.jpg</b> format and can be requested from Dr. Fresia Pareja.</p></li><li><p>Sanger sequencing data: These support figures 2 and 3. They are in <b>SnapGene </b>format and can be requested from Dr. Fresia Pareja. </p></li></ul><p>The corresponding authors for this study are: :</p><p>Dr. Jorge S. Reis-Filho, MD PhD FRCPath, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Phone: +1-212-639-8054. reisfilj@mskcc.org</p><p>Dr. Fresia Pareja, MD PhD, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Phone: +1-212-639-3707/+1-212-639-6070. parejaf@mskcc.org</p><br><p><b>Ethics </b></p><p>Following approval by the Memorial Sloan Kettering Cancer Center Institutional Review Board (IRB) the authors’ institutions, formalin fixed paraffin embedded (FFPE) tissue blocks of three breast PAs and one breast MEC were retrieved from the pathology archives of the authors’ institutions. All samples were anonymized before analysis.</p>